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Following is a message from ABC:
As we begin our search for a new general hospital for the ABC Television Network, we’d like you to share your thoughts. We’ll be conducting a comprehensive survey in several cities nationwide including Charlotte, N.C., to capture your views and opinions.
Please take a few moments to complete the survey on our website. Your participation is appreciated. We’ll be conducting similar surveys in other cities across the country this month.The role of P-glycoprotein in defining the toxicity of cyclophosphamide in rats and mice.
We have previously described the pharmacokinetic interaction between cyclophosphamide (CPA) and vinblastine (VBL) in mice, in which CPA treatment causes a substantial increase in the rate of VBL elimination. In the present studies, the hypothesis that this phenomenon might be related to a genetically mediated, efflux-mediated, CPA-induced increase in P-glycoprotein (P-gp) expression in tissues was investigated. In mouse renal cortical and medullary tissues, the effect of CPA on VBL distribution was significantly reduced in P-gp knockout (P-gp(-/-)) mice compared to wild-type controls. Furthermore,
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